Ekram Al-Eryani *, Abdul-Kafi Shuga’a Al-Dini, Farooq Hayel, Munira Dughish
1Department of Molecular Medicine, Faculty of Medicine, University of Malaya
Department of Biochemistry and Molecular Biology, Faculty of Medicine and Health Sciences, University of Sana`a, Sana`a, Yemen
SUJMS • 2021 | Jane | Vol 15| Issue. (1))
Diabetes mellitus (DM) is a group of metabolic diseases characterized by chronic hyperglycemia resulting from defects in insulin secretion, insulin action, and or both. The chronic hyperglycemia of diabetes is associated with long-term damage, failure of different organs, especially the eyes, kidneys, nerves, heart, and blood vessels . Type 2 DM is caused by insulin resistance, inadequate secretion of insulin, is generally associated with overweight and obesity .
The paraoxonase (PON) enzyme family is constituted by three members: PON1, PON2, and PON3. Paraoxonase-1 (PON1) is the most studied member of the paraoxonase family and is classified as an aryldialkylphosphatase . Paraoxonase-1 is a 44 kD calcium-dependent glycoprotein